Assay Detail
Binding
CHEMBL4829489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type EGFR L858R/T790M/C797S mutant (unknown origin) pretreated with substrate for 10 mins followed by ATP addition measured after 60 mins by mobility shift assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The synthesis and bioactivity of pyrrolo[2,3-d]pyrimidine derivatives as tyrosine kinase inhibitors for NSCLC cells with EGFR mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.52 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4847264 | — | — | 1 | 6.92 |
| CHEMBL4297865 | ABIVERTINIB | 3.0 | 1 | 6.55 |
| CHEMBL4850239 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4847264 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL4297865 | ABIVERTINIB | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL4850239 | — | IC50 | = | 829.0 | nM | 6.08 |