Assay Detail
Functional
CHEMBL4830154
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Antiproliferative activity against human A-375 cells assessed as reduction in cell viability after 96 hrs by alamar blue assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.71 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4861945 | — | — | 1 | 8.54 |
| CHEMBL4847260 | BEROTERKIB ANHYDROUS | 2.0 | 1 | 8.47 |
| CHEMBL4869086 | — | — | 1 | 8.40 |
| CHEMBL4212211 | — | — | 1 | 8.31 |
| CHEMBL4847212 | — | — | 1 | 8.28 |
| CHEMBL4871302 | — | — | 1 | 8.23 |
| CHEMBL4870176 | — | — | 1 | 7.96 |
| CHEMBL4869800 | — | — | 1 | 7.96 |
| CHEMBL4867689 | — | — | 1 | 7.92 |
| CHEMBL4873400 | — | — | 1 | 7.92 |
| CHEMBL4856124 | — | — | 1 | 7.92 |
| CHEMBL4878876 | — | — | 1 | 7.82 |
| CHEMBL4857389 | — | — | 1 | 7.75 |
| CHEMBL4866448 | — | — | 1 | 7.75 |
| CHEMBL4849148 | — | — | 1 | 7.70 |
| CHEMBL4873851 | — | — | 1 | 7.68 |
| CHEMBL4870129 | — | — | 1 | 7.54 |
| CHEMBL4868536 | — | — | 1 | 7.50 |
| CHEMBL4865318 | — | — | 1 | 7.42 |
| CHEMBL4213466 | — | — | 1 | 7.35 |
| CHEMBL4849535 | — | — | 1 | 6.92 |
| CHEMBL4847468 | — | — | 1 | 6.48 |
| CHEMBL4850133 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4861945 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4847260 | BEROTERKIB ANHYDROUS | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4869086 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4212211 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4847212 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4871302 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL4870176 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4869800 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4867689 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4873400 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4856124 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4878876 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4857389 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4866448 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4849148 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4873851 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4870129 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4868536 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4865318 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4213466 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4849535 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4847468 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4850133 | — | IC50 | = | 2500.0 | nM | 5.60 |