Assay Detail
Functional
CHEMBL4830286
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human RCC4/VHL cells assessed as inhibition of cell proliferation measured after 72 hrs by CCK8 reagent assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RCC4/VHL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Study on the structure-activity relationship of dihydroartemisinin derivatives: Discovery, synthesis, and biological evaluation of dihydroartemisinin-bile acid conjugates as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.16 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.22 |
| CHEMBL4854240 | — | — | 1 | 6.17 |
| CHEMBL4859691 | — | — | 1 | 6.02 |
| CHEMBL4854960 | — | — | 1 | 5.75 |
| CHEMBL4862637 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4854240 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4859691 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4854960 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4862637 | — | IC50 | = | 2200.0 | nM | 5.66 |