Assay Detail
Functional
CHEMBL4830320
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A-375 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.13 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4855607 | — | — | 1 | 9.22 |
| CHEMBL492399 | VERUBULIN | 2.0 | 1 | 9.15 |
| CHEMBL4871913 | — | — | 1 | 8.96 |
| CHEMBL4855608 | — | — | 1 | 8.85 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.77 |
| CHEMBL4520878 | — | — | 1 | 8.39 |
| CHEMBL4879163 | — | — | 1 | 8.26 |
| CHEMBL4850900 | — | — | 1 | 8.24 |
| CHEMBL4878879 | — | — | 1 | 8.15 |
| CHEMBL4857102 | — | — | 1 | 8.05 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.96 |
| CHEMBL4876166 | — | — | 1 | 7.92 |
| CHEMBL4858577 | — | — | 1 | 7.87 |
| CHEMBL4876313 | — | — | 1 | 7.84 |
| CHEMBL4849437 | — | — | 1 | 7.82 |
| CHEMBL4863678 | — | — | 1 | 7.50 |
| CHEMBL4088019 | — | — | 1 | 6.96 |
| CHEMBL4075372 | — | — | 1 | 6.43 |
| CHEMBL4859195 | — | — | 1 | - |
| CHEMBL4877188 | — | — | 1 | - |
| CHEMBL4878065 | — | — | 1 | - |
| CHEMBL4845756 | — | — | 1 | - |
| CHEMBL4059730 | — | — | 1 | - |
| CHEMBL4861176 | — | — | 1 | - |
| CHEMBL4864654 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4855607 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL492399 | VERUBULIN | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4871913 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4855608 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4520878 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL4879163 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4850900 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4878879 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL4857102 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL107 | COLCHICINE | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL4876166 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL4858577 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL4876313 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL4849437 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4863678 | — | IC50 | = | 31.8 | nM | 7.50 |
| CHEMBL4088019 | — | IC50 | = | 109.6 | nM | 6.96 |
| CHEMBL4075372 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4859195 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4877188 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4878065 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4845756 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4059730 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4861176 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4864654 | — | IC50 | > | 1000.0 | nM | - |