Assay Detail
Functional
CHEMBL4830324
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Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-453 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.73 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4855608 | — | — | 1 | 9.30 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 9.15 |
| CHEMBL4871913 | — | — | 1 | 9.00 |
| CHEMBL4520878 | — | — | 1 | 8.92 |
| CHEMBL4876166 | — | — | 1 | 8.85 |
| CHEMBL4879163 | — | — | 1 | 8.43 |
| CHEMBL4850900 | — | — | 1 | 8.35 |
| CHEMBL4876313 | — | — | 1 | 8.34 |
| CHEMBL4878879 | — | — | 1 | 8.31 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.24 |
| CHEMBL4858577 | — | — | 1 | 8.14 |
| CHEMBL4845756 | — | — | 1 | 7.51 |
| CHEMBL4855607 | — | — | 1 | 7.38 |
| CHEMBL4857102 | — | — | 1 | 7.37 |
| CHEMBL4088019 | — | — | 1 | 6.98 |
| CHEMBL4849437 | — | — | 1 | 6.89 |
| CHEMBL4863678 | — | — | 1 | 6.71 |
| CHEMBL4075372 | — | — | 1 | 6.42 |
| CHEMBL4864654 | — | — | 1 | 6.25 |
| CHEMBL4861176 | — | — | 1 | 6.16 |
| CHEMBL4877188 | — | — | 1 | 5.59 |
| CHEMBL4859195 | — | — | 1 | - |
| CHEMBL4878065 | — | — | 1 | - |
| CHEMBL4059730 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4855608 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4871913 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4520878 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4876166 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4879163 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4850900 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4876313 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4878879 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL107 | COLCHICINE | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4858577 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL4845756 | — | IC50 | = | 30.6 | nM | 7.51 |
| CHEMBL4855607 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4857102 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4088019 | — | IC50 | = | 105.4 | nM | 6.98 |
| CHEMBL4849437 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL4863678 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL4075372 | — | IC50 | = | 378.7 | nM | 6.42 |
| CHEMBL4864654 | — | IC50 | = | 556.3 | nM | 6.25 |
| CHEMBL4861176 | — | IC50 | = | 692.6 | nM | 6.16 |
| CHEMBL4877188 | — | IC50 | = | 2562.0 | nM | 5.59 |
| CHEMBL4859195 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4878065 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4059730 | — | IC50 | > | 1000.0 | nM | - |