Assay Detail
Binding
CHEMBL4830948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 50 uM NAD+ by fluorescence based analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial (CHEMBL2163183) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.06 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4860183 | — | — | 1 | 5.30 |
| CHEMBL4869330 | — | — | 1 | 5.12 |
| CHEMBL4875043 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4860183 | — | IC50 | = | 5040.0 | nM | 5.30 |
| CHEMBL4869330 | — | IC50 | = | 7620.0 | nM | 5.12 |
| CHEMBL4875043 | — | IC50 | = | 17790.0 | nM | 4.75 |