Assay Detail
Binding
CHEMBL4830951
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant SIRT5 (34 to 269 residues) using 33 uM Ac-Leu-Gly-Ser-Lys(Su)-AMC as substrate incubated for 1 hr in presence of 400 uM NAD+ by fluorescence based analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial (CHEMBL2163183) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.32 | 4.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4860183 | — | — | 1 | 4.53 |
| CHEMBL4869330 | — | — | 1 | 4.24 |
| CHEMBL4875043 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4860183 | — | IC50 | = | 29750.0 | nM | 4.53 |
| CHEMBL4869330 | — | IC50 | = | 56970.0 | nM | 4.24 |
| CHEMBL4875043 | — | IC50 | = | 65320.0 | nM | 4.18 |