Assay Detail
Binding
CHEMBL4830960
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SIRT5 (unknown origin)
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial (CHEMBL2163183) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.42 | 6.96 |
| Ki | 1 | 5.37 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4636862 | — | — | 1 | 6.96 |
| CHEMBL4856582 | — | — | 1 | 5.37 |
| CHEMBL4072635 | — | — | 1 | 5.25 |
| CHEMBL4864451 | — | — | 1 | 5.12 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4636862 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4856582 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL4072635 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4864451 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL265502 | SURAMIN | IC50 | = | 46000.0 | nM | 4.34 |