Assay Detail
Binding
CHEMBL4830962
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SIRT5 (unknown origin) assessed as reduction in GGQSLKFGKG formation using GGQSLK[succ]FGKG as substrate
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial (CHEMBL2163183) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.41 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201346 | BALSALAZIDE | 4.0 | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201346 | BALSALAZIDE | IC50 | = | 3900.0 | nM | 5.41 |