Assay Detail
Functional
CHEMBL4830988
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Cytotoxicity against mouse BaF3 cells harboring EGFR L858R/T790M/C797S triple mutant assessed as inhibition of cell proliferation measured after 72 hrs by MTS assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A sulfonyl fluoride derivative inhibits EGFR<sup>L858R/T790M/C797S</sup> by covalent modification of the catalytic lysine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.30 | 6.30 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866162 | — | — | 1 | 6.30 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | - |
| CHEMBL4855850 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866162 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | > | 3000.0 | nM | - |
| CHEMBL4855850 | — | Activity | - | — | - |