Assay Detail
Binding
CHEMBL4831257
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His6-tagged human p70S6k T412E mutant (1 to 421 residues) expressed in Sf21 cells using FITC-AHA-AKRRRLSSLRA-OH as substrate incubated for 90 mins by mobility shift assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 7.86 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3685329 | — | — | 1 | 9.22 |
| CHEMBL3670464 | — | — | 1 | 9.10 |
| CHEMBL4860970 | — | — | 1 | 9.00 |
| CHEMBL4871853 | — | — | 1 | 9.00 |
| CHEMBL3675415 | — | — | 1 | 9.00 |
| CHEMBL4871106 | RUPITASERTIB | 2.0 | 1 | 8.96 |
| CHEMBL4855657 | — | — | 1 | 8.89 |
| CHEMBL4876446 | — | — | 1 | 8.85 |
| CHEMBL4856439 | — | — | 1 | 8.70 |
| CHEMBL3675355 | — | — | 1 | 8.70 |
| CHEMBL4869229 | — | — | 1 | 8.70 |
| CHEMBL4854144 | — | — | 1 | 8.70 |
| CHEMBL4851020 | — | — | 1 | 8.62 |
| CHEMBL3675442 | — | — | 1 | 8.59 |
| CHEMBL4846712 | — | — | 1 | 8.54 |
| CHEMBL3670413 | — | — | 1 | 8.54 |
| CHEMBL4878044 | — | — | 1 | 8.21 |
| CHEMBL4875416 | — | — | 1 | 8.10 |
| CHEMBL3675344 | — | — | 1 | 7.96 |
| CHEMBL3675354 | — | — | 1 | 7.62 |
| CHEMBL4846770 | — | — | 1 | 7.60 |
| CHEMBL3675353 | — | — | 1 | 7.58 |
| CHEMBL3680423 | — | — | 1 | 7.55 |
| CHEMBL4853030 | — | — | 1 | 7.52 |
| CHEMBL3670457 | — | — | 1 | 7.52 |
| CHEMBL3680434 | — | — | 1 | 7.51 |
| CHEMBL3675337 | — | — | 1 | 7.50 |
| CHEMBL3675340 | — | — | 1 | 7.41 |
| CHEMBL3675343 | — | — | 1 | 7.38 |
| CHEMBL3675333 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3685329 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3670464 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4871853 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3675415 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4860970 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4871106 | RUPITASERTIB | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4855657 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4876446 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4856439 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3675355 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4869229 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4854144 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4851020 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3675442 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3670413 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4846712 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4878044 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4875416 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3675344 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3675354 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4846770 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3675353 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3680423 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3670457 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4853030 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3680434 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3675337 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3675340 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3675343 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3675333 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4857965 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3680521 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3670427 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3639742 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL3680537 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL3675357 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4870165 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3675347 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL3675352 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3675367 | — | IC50 | = | 644.0 | nM | 6.19 |
| CHEMBL4878255 | — | IC50 | = | 973.0 | nM | 6.01 |
| CHEMBL4847586 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4875216 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4861175 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4853114 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4859445 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL102726 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4872249 | — | IC50 | > | 10000.0 | nM | - |