Assay Detail
Binding
CHEMBL4832705
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kalpha (unknown origin) using L-alpha-phosphatidylinositol as substrate incubated for 30 to 60 mins in presence of ATP by Kinase Glo luminescence kinase assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.40 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4864109 | — | — | 1 | 7.47 |
| CHEMBL4855904 | — | — | 1 | 7.46 |
| CHEMBL4867254 | — | — | 1 | 7.43 |
| CHEMBL4857826 | — | — | 1 | 7.26 |
| CHEMBL4863328 | — | — | 1 | 7.20 |
| CHEMBL4866794 | — | — | 1 | 7.03 |
| CHEMBL4859017 | — | — | 1 | 6.96 |
| CHEMBL4850655 | — | — | 1 | 6.77 |
| CHEMBL4878811 | — | — | 1 | 6.70 |
| CHEMBL4848126 | — | — | 1 | 6.54 |
| CHEMBL4878615 | — | — | 1 | 6.52 |
| CHEMBL4868011 | — | — | 1 | 6.35 |
| CHEMBL4857001 | — | — | 1 | 6.34 |
| CHEMBL4849042 | — | — | 1 | 6.28 |
| CHEMBL4859466 | — | — | 1 | 6.24 |
| CHEMBL4857607 | — | — | 1 | 6.21 |
| CHEMBL4854845 | — | — | 1 | 6.19 |
| CHEMBL4876331 | — | — | 1 | 6.06 |
| CHEMBL4878721 | — | — | 1 | 6.06 |
| CHEMBL4861144 | — | — | 1 | 6.05 |
| CHEMBL4846278 | — | — | 1 | 6.02 |
| CHEMBL4854857 | — | — | 1 | 5.80 |
| CHEMBL4873556 | — | — | 1 | 5.77 |
| CHEMBL2071342 | — | — | 1 | 5.52 |
| CHEMBL4866311 | — | — | 1 | 5.12 |
| CHEMBL4855444 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4864109 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4855904 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4867254 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4857826 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4863328 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4866794 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4859017 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4850655 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL4878811 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4848126 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4878615 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4868011 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4857001 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4849042 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4859466 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4857607 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4854845 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4876331 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4878721 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4861144 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4846278 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4854857 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4873556 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2071342 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL4866311 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4855444 | — | IC50 | = | 9400.0 | nM | 5.03 |