Assay Detail
Binding
CHEMBL4833047
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PTP1B (1 to 322 residues) expressed in Escherichia coli using pNPP as substrate preincubated with substrate for 10 mins followed by enzyme addition and measured for 10 mins by absorbance based analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dual High-Resolution α-Glucosidase and PTP1B Inhibition Profiling Combined with HPLC-PDA-HRMS-SPE-NMR Analysis for the Identification of Potentially Antidiabetic Chromene Meroterpenoids from <i>Rhododendron capitatum</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.02 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL508583 | TRODUSQUEMINE | 2.0 | 1 | 6.00 |
| CHEMBL184041 | ERTIPROTAFIB | 2.0 | 1 | 5.80 |
| CHEMBL2310311 | — | — | 1 | 5.60 |
| CHEMBL513978 | GRIFOLIC ACID | — | 1 | 5.44 |
| CHEMBL4866095 | — | — | 1 | 5.22 |
| CHEMBL4876070 | — | — | 1 | 4.99 |
| CHEMBL4856719 | — | — | 1 | 4.70 |
| CHEMBL4847372 | — | — | 1 | 4.55 |
| CHEMBL4849561 | — | — | 1 | 4.44 |
| CHEMBL4854129 | — | — | 1 | 4.27 |
| CHEMBL4859368 | — | — | 1 | 4.17 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | - |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | - |
| CHEMBL4874393 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL508583 | TRODUSQUEMINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL184041 | ERTIPROTAFIB | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2310311 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL513978 | GRIFOLIC ACID | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4866095 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4876070 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4856719 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL4847372 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL4849561 | — | IC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL4854129 | — | IC50 | = | 53600.0 | nM | 4.27 |
| CHEMBL4859368 | — | IC50 | = | 68100.0 | nM | 4.17 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | - | — | - | |
| CHEMBL169 | URSOLIC ACID | IC50 | - | — | - | |
| CHEMBL4874393 | — | IC50 | - | — | - |