Assay Detail
Binding
CHEMBL4833200
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FGFR1 (unknown origin) using poly-GT as substrate preincubated for 1 hr followed by substrate addition and measured after 1 hr by FRET assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of quinazoline derivatives as potent and selective FGFR4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.50 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3939295 | H3B-6527 | 1.0 | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3939295 | H3B-6527 | IC50 | = | 320.0 | nM | 6.50 |