Assay Detail
Functional
CHEMBL4833216
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 harboring reverse transcriptase E138K mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect incubated for 5 days by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.63 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4855307 | — | — | 1 | 8.31 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.22 |
| CHEMBL4860247 | — | — | 1 | 8.17 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.82 |
| CHEMBL4875519 | — | — | 1 | 7.72 |
| CHEMBL4877758 | — | — | 1 | 7.21 |
| CHEMBL4847927 | — | — | 1 | 6.84 |
| CHEMBL4867738 | — | — | 1 | 6.77 |
| CHEMBL4865966 | — | — | 1 | - |
| CHEMBL4876956 | — | — | 1 | - |
| CHEMBL4861244 | — | — | 1 | - |
| CHEMBL4861514 | — | — | 1 | - |
| CHEMBL4866808 | — | — | 1 | - |
| CHEMBL4851873 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4855307 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4860247 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 15.2 | nM | 7.82 |
| CHEMBL4875519 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4877758 | — | EC50 | = | 61.3 | nM | 7.21 |
| CHEMBL4847927 | — | EC50 | = | 146.0 | nM | 6.84 |
| CHEMBL4867738 | — | EC50 | = | 171.0 | nM | 6.77 |
| CHEMBL4865966 | — | EC50 | > | 4518.0 | nM | - |
| CHEMBL4876956 | — | EC50 | > | 8829.0 | nM | - |
| CHEMBL4861244 | — | EC50 | > | 25785.0 | nM | - |
| CHEMBL4861514 | — | EC50 | > | 69114.0 | nM | - |
| CHEMBL4866808 | — | EC50 | > | 41309.0 | nM | - |
| CHEMBL4851873 | — | EC50 | > | 707.0 | nM | - |