Assay Detail
Functional
CHEMBL4833221
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 harboring reverse transcriptase F227L/V106A double mutant infected in human MT4 cells assessed as protection against virus-induced cytopathic effect incubated for 5 days by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.77 | 7.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.59 |
| CHEMBL4875519 | — | — | 1 | 7.23 |
| CHEMBL4877758 | — | — | 1 | 7.02 |
| CHEMBL4855307 | — | — | 1 | 6.99 |
| CHEMBL4860247 | — | — | 1 | 6.84 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.56 |
| CHEMBL4867738 | — | — | 1 | 6.28 |
| CHEMBL4847927 | — | — | 1 | 5.65 |
| CHEMBL4865966 | — | — | 1 | - |
| CHEMBL4876956 | — | — | 1 | - |
| CHEMBL4861244 | — | — | 1 | - |
| CHEMBL4861514 | — | — | 1 | - |
| CHEMBL4866808 | — | — | 1 | - |
| CHEMBL4851873 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 25.7 | nM | 7.59 |
| CHEMBL4875519 | — | EC50 | = | 58.4 | nM | 7.23 |
| CHEMBL4877758 | — | EC50 | = | 95.3 | nM | 7.02 |
| CHEMBL4855307 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL4860247 | — | EC50 | = | 146.0 | nM | 6.84 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 274.0 | nM | 6.56 |
| CHEMBL4867738 | — | EC50 | = | 524.0 | nM | 6.28 |
| CHEMBL4847927 | — | EC50 | = | 2245.0 | nM | 5.65 |
| CHEMBL4865966 | — | EC50 | > | 4518.0 | nM | - |
| CHEMBL4876956 | — | EC50 | > | 8829.0 | nM | - |
| CHEMBL4861244 | — | EC50 | > | 25785.0 | nM | - |
| CHEMBL4861514 | — | EC50 | > | 69114.0 | nM | - |
| CHEMBL4866808 | — | EC50 | > | 41309.0 | nM | - |
| CHEMBL4851873 | — | EC50 | > | 707.0 | nM | - |