Assay Detail
Functional
CHEMBL4833900
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against amastigote stage of Leishmania infantum MHOM/MA(BE)/67/ITMAP263 infected in mouse peritoneal macrophage assessed as reduction in parasite burden incubated for 5 days by Giemsa staining based microscopic analysis
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Cell Type | Peritoneal macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 5.56 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4864912 | — | — | 1 | 6.30 |
| CHEMBL4853379 | — | — | 1 | 6.30 |
| CHEMBL4868645 | — | — | 1 | 6.23 |
| CHEMBL4874617 | — | — | 1 | 6.22 |
| CHEMBL4857581 | — | — | 1 | 6.19 |
| CHEMBL4862187 | — | — | 1 | 6.10 |
| CHEMBL4859733 | — | — | 1 | 5.89 |
| CHEMBL4846846 | — | — | 1 | 5.89 |
| CHEMBL4849214 | — | — | 1 | 5.85 |
| CHEMBL4847520 | — | — | 1 | 5.80 |
| CHEMBL4857278 | — | — | 1 | 5.80 |
| CHEMBL4873099 | — | — | 1 | 5.77 |
| CHEMBL4455345 | — | — | 1 | 5.77 |
| CHEMBL4847418 | — | — | 1 | 5.75 |
| CHEMBL4874673 | — | — | 1 | 5.75 |
| CHEMBL4848737 | — | — | 1 | 5.70 |
| CHEMBL4871287 | — | — | 1 | 5.68 |
| CHEMBL4872513 | — | — | 1 | 5.66 |
| CHEMBL2441392 | — | — | 1 | 5.57 |
| CHEMBL4850767 | — | — | 1 | 5.52 |
| CHEMBL4859032 | — | — | 1 | 5.51 |
| CHEMBL4846571 | — | — | 1 | 5.24 |
| CHEMBL4875612 | — | — | 1 | 5.24 |
| CHEMBL4862021 | — | — | 1 | 5.19 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.00 |
| CHEMBL4846529 | — | — | 1 | 4.85 |
| CHEMBL4871532 | — | — | 1 | 4.80 |
| CHEMBL4854414 | — | — | 1 | 4.47 |
| CHEMBL4865994 | — | — | 1 | 4.43 |
| CHEMBL4865151 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4864912 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4853379 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4868645 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4874617 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4857581 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4862187 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4859733 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4846846 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4849214 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4847520 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4857278 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4873099 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4455345 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4847418 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4874673 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4848737 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4871287 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4872513 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2441392 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4850767 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4859032 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4846571 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4875612 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4862021 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL125 | MILTEFOSINE | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4846529 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4871532 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4854414 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4865994 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4865151 | — | EC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL2347704 | ACOZIBOROLE | EC50 | > | 64000.0 | nM | - |