Assay Detail
Functional
CHEMBL4834034
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Antiproliferative activity against human MOLM-13 assessed as reduction in cell viability incubated for 72 hrs by Cell titer-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Heterocyclic Compounds as Dihydroorotate Dehydrogenase Inhibitors for Treating Acute Myelogenous Leukemia (AML).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.50 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854356 | — | — | 1 | 9.70 |
| CHEMBL4855859 | — | — | 1 | 9.52 |
| CHEMBL4859161 | — | — | 1 | 9.52 |
| CHEMBL4852401 | — | — | 1 | 9.52 |
| CHEMBL4857243 | — | — | 1 | 9.40 |
| CHEMBL4851260 | — | — | 1 | 9.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854356 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4855859 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4859161 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4852401 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4857243 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4851260 | — | IC50 | = | 0.46 | nM | 9.34 |