Assay Detail
Functional
CHEMBL4834206
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.33 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.26 |
| CHEMBL4875150 | — | — | 1 | 6.00 |
| CHEMBL4860351 | — | — | 1 | 5.96 |
| CHEMBL4847367 | — | — | 1 | 5.92 |
| CHEMBL4866848 | — | — | 1 | 5.89 |
| CHEMBL4878062 | — | — | 1 | 5.80 |
| CHEMBL4865658 | — | — | 1 | 5.75 |
| CHEMBL4853057 | — | — | 1 | 5.75 |
| CHEMBL4859874 | — | — | 1 | 5.75 |
| CHEMBL4858919 | — | — | 1 | 5.65 |
| CHEMBL4871872 | — | — | 1 | 5.57 |
| CHEMBL4878702 | — | — | 1 | 5.57 |
| CHEMBL4868139 | — | — | 1 | 5.56 |
| CHEMBL4851817 | — | — | 1 | 5.55 |
| CHEMBL4846899 | — | — | 1 | 5.54 |
| CHEMBL4864896 | — | — | 1 | 5.53 |
| CHEMBL4852643 | — | — | 1 | 5.52 |
| CHEMBL4859358 | — | — | 1 | 5.50 |
| CHEMBL4878869 | — | — | 1 | 5.42 |
| CHEMBL4876212 | — | — | 1 | 5.38 |
| CHEMBL4865799 | — | — | 1 | 5.37 |
| CHEMBL4865411 | — | — | 1 | 5.36 |
| CHEMBL4853452 | — | — | 1 | 5.35 |
| CHEMBL4868544 | — | — | 1 | 5.28 |
| CHEMBL4868646 | — | — | 1 | 5.24 |
| CHEMBL4877106 | — | — | 1 | 5.21 |
| CHEMBL4872364 | — | — | 1 | 5.21 |
| CHEMBL4862216 | — | — | 1 | 5.18 |
| CHEMBL4852105 | — | — | 1 | 5.16 |
| CHEMBL4876534 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105 | MITOMYCIN | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4875150 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4860351 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4847367 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4866848 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL4878062 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4865658 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL4853057 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4859874 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL4858919 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL4878702 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4871872 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4868139 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL4851817 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL4846899 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL4864896 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL4852643 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL4859358 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL4878869 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL4876212 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL4865799 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL4865411 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL4853452 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL4868544 | — | IC50 | = | 5270.0 | nM | 5.28 |
| CHEMBL4868646 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL4877106 | — | IC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL4872364 | — | IC50 | = | 6190.0 | nM | 5.21 |
| CHEMBL4862216 | — | IC50 | = | 6550.0 | nM | 5.18 |
| CHEMBL4876534 | — | IC50 | = | 6860.0 | nM | 5.16 |
| CHEMBL4852105 | — | IC50 | = | 6890.0 | nM | 5.16 |
| CHEMBL563939 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4298697 | — | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL4845968 | — | IC50 | = | 13440.0 | nM | 4.87 |
| CHEMBL4863676 | — | IC50 | = | 32890.0 | nM | 4.48 |
| CHEMBL4865054 | — | IC50 | = | 50010.0 | nM | 4.30 |
| CHEMBL4861890 | — | IC50 | = | 64310.0 | nM | 4.19 |
| CHEMBL4869475 | — | IC50 | = | 87690.0 | nM | 4.06 |
| CHEMBL1085588 | — | IC50 | = | 89910.0 | nM | 4.05 |