Assay Detail
Functional
CHEMBL4834258
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferation assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3-d]pyrimidine RET Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.54 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4858720 | — | — | 1 | 5.89 |
| CHEMBL169390 | — | — | 1 | 5.80 |
| CHEMBL4857808 | — | — | 1 | 5.58 |
| CHEMBL4853155 | — | — | 1 | 5.43 |
| CHEMBL4859681 | — | — | 1 | 5.39 |
| CHEMBL4877264 | — | — | 1 | 5.34 |
| CHEMBL4874648 | — | — | 1 | 5.34 |
| CHEMBL4864386 | — | — | 1 | - |
| CHEMBL4848347 | — | — | 1 | - |
| CHEMBL4854822 | — | — | 1 | - |
| CHEMBL4855562 | — | — | 1 | - |
| CHEMBL4860822 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4858720 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL169390 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4857808 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4853155 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4859681 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4877264 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4874648 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4864386 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4848347 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4854822 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4855562 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4860822 | — | IC50 | > | 10000.0 | nM | - |