Assay Detail
Functional
CHEMBL4834977
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Agonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship Studies of Coumarin-like Diacid Derivatives as Human G Protein-Coupled Receptor-35 (hGPR35) Agonists and a Consequent New Design Principle.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.10 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4857772 | — | — | 1 | 9.51 |
| CHEMBL3306990 | — | — | 1 | 8.97 |
| CHEMBL4876009 | — | — | 1 | 8.29 |
| CHEMBL4856506 | — | — | 1 | 8.16 |
| CHEMBL4852667 | — | — | 1 | 8.09 |
| CHEMBL4850743 | — | — | 1 | 7.90 |
| CHEMBL4856029 | — | — | 1 | 7.59 |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 7.20 |
| CHEMBL4870213 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4857772 | — | EC50 | = | 0.31 | nM | 9.51 |
| CHEMBL3306990 | — | EC50 | = | 1.08 | nM | 8.97 |
| CHEMBL4876009 | — | EC50 | = | 5.08 | nM | 8.29 |
| CHEMBL4856506 | — | EC50 | = | 6.93 | nM | 8.16 |
| CHEMBL4852667 | — | EC50 | = | 8.13 | nM | 8.09 |
| CHEMBL4850743 | — | EC50 | = | 12.72 | nM | 7.90 |
| CHEMBL4856029 | — | EC50 | = | 25.92 | nM | 7.59 |
| CHEMBL28079 | ZAPRINAST | EC50 | = | 62.83 | nM | 7.20 |
| CHEMBL4870213 | — | EC50 | = | 62.83 | nM | 7.20 |