Assay Detail
Functional
CHEMBL4835009
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Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo luminescent assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.07 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4862901 | — | — | 1 | 7.20 |
| CHEMBL4870385 | — | — | 1 | 7.05 |
| CHEMBL4856793 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4862901 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4870385 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4856793 | — | EC50 | = | 110.0 | nM | 6.96 |