Assay Detail

CHEMBL4835010

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Functional

Cytotoxicity against human OCI-LY10 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo luminescent assay

ChEMBL ↗

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Target

OCI-Ly10 (CHEMBL4483285) ↗

Open DB target context

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OCI-Ly10 (CHEMBL4483285) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target OCI-Ly10

CHEMBL4483285

Anchored from Assay target.

Protein identity OCI-Ly10

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	OCI-Ly10
Confidence	1 — Organism
Curated By	Autocuration

Target

OCI-Ly10 (CHEMBL4483285) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.

Langston SP, Grossman S, England D, Afroze R, Bence N, Bowman D, Bump N, Chau R, Chuang BC, Claiborne C, Cohen L, Connolly K, Duffey M, Durvasula N, Freeze S, Gallery M, Galvin K, Gaulin J, Gershman R, Greenspan P, Grieves J, Guo J, Gulavita N, Hailu S, He X, Hoar K, Hu Y, Hu Z, Ito M, Kim MS, Lane SW, Lok D, Lublinsky A, Mallender W, McIntyre C, Minissale J, Mizutani H, Mizutani M, Molchinova N, Ono K, Patil A, Qian M, Riceberg J, Shindi V, Sintchak MD, Song K, Soucy T, Wang Y, Xu H, Yang X, Zawadzka A, Zhang J, Pulukuri SM.
J Med Chem (2021) 64 : 2501 -2520
PubMed 33631934 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	3	8.02	8.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4856793	—	—	1	8.40
CHEMBL4862901	—	—	1	8.40
CHEMBL4870385	—	—	1	7.26

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4856793	—	EC50	=	4.0	nM	8.40
CHEMBL4862901	—	EC50	=	4.0	nM	8.40
CHEMBL4870385	—	EC50	=	55.0	nM	7.26