Assay Detail
Binding
CHEMBL4835359
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse TRPM1 expressed in HEK293T cells assessed as blocked of capsaicin-activated current at 10 uM by whole cell patch clamp electrophysiology relative to control
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily M member 1 (CHEMBL4879460) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
The Discovery of Novel ACA Derivatives as Specific TRPM2 Inhibitors that Reduce Ischemic Injury Both In Vitro and In Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| IC50 | 1 | 8.22 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122413 | — | — | 1 | 8.22 |
| CHEMBL4863549 | — | — | 1 | - |
| CHEMBL4863360 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122413 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4863549 | — | Inhibition | = | 12.7 | % | - |
| CHEMBL4863360 | — | Inhibition | = | 5.4 | % | - |