Compound Detail
CHEMBL4863360
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Basic Information
| ChEMBL ID | CHEMBL4863360 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YXPPMAGFWDUHJF-JLHYYAGUSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
388.4
MW (Da)
4.61
ALogP
4
HBA
2
HBD
109.5
PSA (Ų)
0.36
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily M member 2 CHEMBL1250402 | IC50 | 6.4 | 6.4 | 398.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily M member 2 | IC50 | = | 398.0 | nM | 6.4 | Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR... | 33784097 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33784097 | 10.1021/acs.jmedchem.0c02129 | Transient receptor potential cation channel subfamily M member 2 | 3 |
| 33784097 | 10.1021/acs.jmedchem.0c02129 | SH-SY5Y | 3 |
| 33784097 | 10.1021/acs.jmedchem.0c02129 | Transient receptor potential cation channel subfamily M member 8 | 1 |
| 33784097 | 10.1021/acs.jmedchem.0c02129 | Transient receptor potential cation channel subfamily M member 1 | 1 |
| 33784097 | 10.1021/acs.jmedchem.0c02129 | Phospholipase A2 | 1 |
Data from ChEMBL 36 via Core Engine