Assay Detail
Functional
CHEMBL4835539
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Antiproliferative activity against MATP-null human HCT-116 cells isogenic cell model assessed as maximal cell growth inhibition at 20 uM incubated for 96 hrs by Cell Titer-Glo assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous <i>MTAP</i> Deletion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.89 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4521249 | — | — | 1 | 7.14 |
| CHEMBL4558617 | — | — | 1 | 7.10 |
| CHEMBL4573938 | — | — | 1 | 6.59 |
| CHEMBL4529030 | — | — | 1 | 6.39 |
| CHEMBL4584451 | — | — | 1 | 6.37 |
| CHEMBL4514699 | — | — | 1 | 6.28 |
| CHEMBL4582312 | — | — | 1 | 6.28 |
| CHEMBL4568226 | — | — | 1 | 6.10 |
| CHEMBL4585665 | — | — | 1 | 6.09 |
| CHEMBL4865263 | — | — | 1 | 4.14 |
| CHEMBL4874436 | — | — | 1 | 4.12 |
| CHEMBL4878283 | — | — | 1 | 4.09 |
| CHEMBL4559088 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4521249 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4558617 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4573938 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL4529030 | — | IC50 | = | 409.0 | nM | 6.39 |
| CHEMBL4584451 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4514699 | — | IC50 | = | 527.0 | nM | 6.28 |
| CHEMBL4582312 | — | IC50 | = | 522.0 | nM | 6.28 |
| CHEMBL4568226 | — | IC50 | = | 793.0 | nM | 6.10 |
| CHEMBL4585665 | — | IC50 | = | 812.0 | nM | 6.09 |
| CHEMBL4865263 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL4874436 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL4878283 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL4559088 | — | IC50 | = | 892000.0 | nM | - |