Assay Detail
ADMET
CHEMBL4835675
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Cytotoxicity against CHO cells assessed as inhibition of cell viability by MTT assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure-Activity Relationship and <i>In Vivo</i> Oral Efficacy Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 4.76 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50588 | EMETINE | 4.0 | 1 | 7.70 |
| CHEMBL4853001 | — | — | 1 | 5.69 |
| CHEMBL4870469 | — | — | 1 | 5.00 |
| CHEMBL4851109 | — | — | 1 | 4.92 |
| CHEMBL4873354 | — | — | 1 | 4.85 |
| CHEMBL4879028 | — | — | 1 | 4.78 |
| CHEMBL4863267 | — | — | 1 | 4.76 |
| CHEMBL4872706 | — | — | 1 | 4.73 |
| CHEMBL4873869 | — | — | 1 | 4.73 |
| CHEMBL4851661 | — | — | 1 | 4.59 |
| CHEMBL4851068 | — | — | 1 | 4.53 |
| CHEMBL4869087 | — | — | 1 | 4.52 |
| CHEMBL4874844 | — | — | 1 | 4.52 |
| CHEMBL4859244 | — | — | 1 | 4.48 |
| CHEMBL4851058 | — | — | 1 | 4.47 |
| CHEMBL4879051 | — | — | 1 | 4.47 |
| CHEMBL4876958 | — | — | 1 | 4.47 |
| CHEMBL4873489 | — | — | 1 | 4.44 |
| CHEMBL4876226 | — | — | 1 | 4.41 |
| CHEMBL4858906 | — | — | 1 | 4.40 |
| CHEMBL4849845 | — | — | 1 | 4.38 |
| CHEMBL4846549 | — | — | 1 | 4.34 |
| CHEMBL4866911 | — | — | 1 | 4.32 |
| CHEMBL4865588 | — | — | 1 | - |
| CHEMBL4862528 | — | — | 1 | - |
| CHEMBL4865127 | — | — | 1 | - |
| CHEMBL4869041 | — | — | 1 | - |
| CHEMBL4851055 | — | — | 1 | - |
| CHEMBL4846454 | — | — | 1 | - |
| CHEMBL4870248 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50588 | EMETINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4853001 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL4870469 | — | IC50 | = | 10040.0 | nM | 5.00 |
| CHEMBL4851109 | — | IC50 | = | 11990.0 | nM | 4.92 |
| CHEMBL4873354 | — | IC50 | = | 14190.0 | nM | 4.85 |
| CHEMBL4879028 | — | IC50 | = | 16650.0 | nM | 4.78 |
| CHEMBL4863267 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL4872706 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL4873869 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL4851661 | — | IC50 | = | 25780.0 | nM | 4.59 |
| CHEMBL4851068 | — | IC50 | = | 29310.0 | nM | 4.53 |
| CHEMBL4874844 | — | IC50 | = | 30460.0 | nM | 4.52 |
| CHEMBL4869087 | — | IC50 | = | 30030.0 | nM | 4.52 |
| CHEMBL4859244 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL4876958 | — | IC50 | = | 33880.0 | nM | 4.47 |
| CHEMBL4851058 | — | IC50 | = | 34150.0 | nM | 4.47 |
| CHEMBL4879051 | — | IC50 | = | 33810.0 | nM | 4.47 |
| CHEMBL4873489 | — | IC50 | = | 36280.0 | nM | 4.44 |
| CHEMBL4876226 | — | IC50 | = | 39040.0 | nM | 4.41 |
| CHEMBL4858906 | — | IC50 | = | 39740.0 | nM | 4.40 |
| CHEMBL4849845 | — | IC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL4846549 | — | IC50 | = | 45790.0 | nM | 4.34 |
| CHEMBL4866911 | — | IC50 | = | 47560.0 | nM | 4.32 |
| CHEMBL4862272 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4852248 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4879217 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4853530 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4875424 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4871841 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4846075 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4853995 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4861409 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4852597 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4878773 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4857300 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4870248 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4846454 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4851055 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4869041 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4865127 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4862528 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4865588 | — | IC50 | > | 50000.0 | nM | - |