Assay Detail
Binding
CHEMBL4835860
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NAAA (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
N-acylethanolamine-hydrolyzing acid amidase (CHEMBL4349) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and Structure-Activity Relationships of Isothiocyanates as Potent and Selective <i>N</i>-Acylethanolamine-Hydrolyzing Acid Amidase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.86 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4633213 | — | — | 1 | 9.05 |
| CHEMBL4642907 | — | — | 1 | 8.55 |
| CHEMBL4647961 | — | — | 1 | 8.22 |
| CHEMBL2419814 | — | — | 1 | 8.15 |
| CHEMBL2064166 | — | — | 1 | 8.15 |
| CHEMBL4215669 | — | — | 1 | 8.05 |
| CHEMBL3770558 | — | — | 1 | 7.48 |
| CHEMBL4871398 | — | — | 1 | 6.64 |
| CHEMBL3770509 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4633213 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4642907 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4647961 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2419814 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2064166 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4215669 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3770558 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4871398 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3770509 | — | IC50 | = | 340.0 | nM | 6.47 |