Assay Detail
Binding
CHEMBL4836057
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stabilization of AL patient derived full length fluorescein-labeled IGLV6-57 expressed in Escherichia coli BL21 (DE3) measured after 24 hrs by proteolysis coupled-fluorescence polarization assay
44
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Immunoglobulin lambda variable 6-57 (CHEMBL4739844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 44 | 6.32 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4874211 | — | — | 1 | 8.39 |
| CHEMBL4866500 | — | — | 2 | 8.07 |
| CHEMBL4870683 | — | — | 1 | 8.06 |
| CHEMBL4856046 | — | — | 1 | 7.60 |
| CHEMBL4848583 | — | — | 1 | 7.45 |
| CHEMBL4859730 | — | — | 1 | 7.32 |
| CHEMBL4866739 | — | — | 1 | 7.21 |
| CHEMBL4854105 | — | — | 1 | 7.15 |
| CHEMBL4855805 | — | — | 1 | 7.11 |
| CHEMBL4862037 | — | — | 1 | 6.99 |
| CHEMBL4856361 | — | — | 1 | 6.96 |
| CHEMBL4849658 | — | — | 1 | 6.82 |
| CHEMBL4858385 | — | — | 1 | 6.82 |
| CHEMBL4846353 | — | — | 1 | 6.68 |
| CHEMBL4850480 | — | — | 1 | 6.54 |
| CHEMBL4872061 | — | — | 1 | 6.54 |
| CHEMBL4855362 | — | — | 1 | 6.52 |
| CHEMBL4848404 | — | — | 2 | 6.52 |
| CHEMBL4871026 | — | — | 1 | 6.50 |
| CHEMBL4867929 | — | — | 1 | 6.38 |
| CHEMBL4859449 | — | — | 1 | 6.26 |
| CHEMBL4875945 | — | — | 1 | 6.25 |
| CHEMBL4877002 | — | — | 1 | 6.09 |
| CHEMBL4871041 | — | — | 1 | 6.07 |
| CHEMBL4854803 | — | — | 1 | 5.96 |
| CHEMBL4861156 | — | — | 1 | 5.86 |
| CHEMBL4860180 | — | — | 1 | 5.77 |
| CHEMBL4849620 | — | — | 1 | 5.71 |
| CHEMBL4878847 | — | — | 1 | 5.70 |
| CHEMBL4879274 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4874211 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL4866500 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4870683 | — | EC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4866500 | — | EC50 | = | 11.5 | nM | 7.94 |
| CHEMBL4856046 | — | EC50 | = | 25.2 | nM | 7.60 |
| CHEMBL4848583 | — | EC50 | = | 35.6 | nM | 7.45 |
| CHEMBL4859730 | — | EC50 | = | 48.1 | nM | 7.32 |
| CHEMBL4866739 | — | EC50 | = | 62.4 | nM | 7.21 |
| CHEMBL4854105 | — | EC50 | = | 71.1 | nM | 7.15 |
| CHEMBL4855805 | — | EC50 | = | 77.1 | nM | 7.11 |
| CHEMBL4862037 | — | EC50 | = | 103.0 | nM | 6.99 |
| CHEMBL4856361 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4858385 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4849658 | — | EC50 | = | 151.0 | nM | 6.82 |
| CHEMBL4846353 | — | EC50 | = | 207.0 | nM | 6.68 |
| CHEMBL4872061 | — | EC50 | = | 289.0 | nM | 6.54 |
| CHEMBL4850480 | — | EC50 | = | 292.0 | nM | 6.54 |
| CHEMBL4855362 | — | EC50 | = | 302.0 | nM | 6.52 |
| CHEMBL4848404 | — | EC50 | = | 299.0 | nM | 6.52 |
| CHEMBL4871026 | — | EC50 | = | 313.0 | nM | 6.50 |
| CHEMBL4867929 | — | EC50 | = | 415.0 | nM | 6.38 |
| CHEMBL4848404 | — | EC50 | = | 477.0 | nM | 6.32 |
| CHEMBL4859449 | — | EC50 | = | 551.0 | nM | 6.26 |
| CHEMBL4875945 | — | EC50 | = | 558.0 | nM | 6.25 |
| CHEMBL4877002 | — | EC50 | = | 816.0 | nM | 6.09 |
| CHEMBL4871041 | — | EC50 | = | 855.0 | nM | 6.07 |
| CHEMBL4854803 | — | EC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4861156 | — | EC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL4860180 | — | EC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL4849620 | — | EC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4878847 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4879274 | — | EC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL4852917 | — | EC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL4847400 | — | EC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL315348 | — | EC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL4877901 | — | EC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL4859852 | — | EC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL4875269 | — | EC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL4854056 | — | EC50 | = | 7890.0 | nM | 5.10 |
| CHEMBL4879384 | — | EC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL4854892 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4851449 | — | EC50 | = | 18803.0 | nM | 4.73 |
| CHEMBL4848237 | — | EC50 | = | 26003.0 | nM | 4.58 |
| CHEMBL4856004 | — | EC50 | - | — | - |