Assay Detail
Functional
CHEMBL4836455
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Antiproliferative activity against mouse KIF5B-RET BaF3 cells by cell based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and optimization of selective RET inhibitors via scaffold hopping.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.77 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4872605 | — | — | 1 | 7.85 |
| CHEMBL4582651 | PRALSETINIB | 4.0 | 1 | 7.77 |
| CHEMBL4870957 | — | — | 1 | 7.72 |
| CHEMBL4846521 | — | — | 1 | 7.72 |
| CHEMBL4845703 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4872605 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4582651 | PRALSETINIB | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4870957 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4846521 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4845703 | — | IC50 | - | — | - |