Assay Detail
Functional
CHEMBL4836638
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-induced MCP1 production in human whole blood incubated for 30 mins followed by LPS stimulation and measured after 24 hrs by mesoscale assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.15 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4869149 | — | — | 1 | 7.80 |
| CHEMBL4851125 | — | — | 1 | 7.00 |
| CHEMBL4850119 | — | — | 1 | 7.00 |
| CHEMBL4848969 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4869149 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL4851125 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4850119 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4848969 | — | IC50 | = | 158.49 | nM | 6.80 |