Assay Detail
Binding
CHEMBL4836859
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length His-tagged p110beta expressed in baculovirus expression system measured after 60 mins in presence of ATP by ATP-competitive binding assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3Kδ-specific inhibitors for the treatment of hematologic malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.47 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4862467 | — | — | 1 | 7.06 |
| CHEMBL4876309 | — | — | 1 | 6.89 |
| CHEMBL4845946 | — | — | 1 | 6.84 |
| CHEMBL4868117 | — | — | 1 | 6.79 |
| CHEMBL4874404 | — | — | 1 | 6.70 |
| CHEMBL4852166 | — | — | 1 | 6.70 |
| CHEMBL4871071 | — | — | 1 | 6.60 |
| CHEMBL4852863 | — | — | 1 | 6.54 |
| CHEMBL4874496 | — | — | 1 | 6.36 |
| CHEMBL4876188 | — | — | 1 | 6.33 |
| CHEMBL4858100 | — | — | 1 | 6.25 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 6.21 |
| CHEMBL4870032 | — | — | 1 | 6.07 |
| CHEMBL4853740 | — | — | 1 | 5.98 |
| CHEMBL4847494 | — | — | 1 | 5.78 |
| CHEMBL4854194 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4862467 | — | IC50 | = | 87.6 | nM | 7.06 |
| CHEMBL4876309 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL4845946 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4868117 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL4874404 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4852166 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL4871071 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4852863 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL4874496 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4876188 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4858100 | — | IC50 | = | 562.0 | nM | 6.25 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 613.0 | nM | 6.21 |
| CHEMBL4870032 | — | IC50 | = | 854.0 | nM | 6.07 |
| CHEMBL4853740 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL4847494 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4854194 | — | IC50 | > | 1000.0 | nM | - |