Assay Detail
Functional
CHEMBL4836950
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H929 cells assessed as decrease in cell viability measured after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H929 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 3,5-Dimethyl-4-Sulfonyl-1<i>H</i>-Pyrrole-Based Myeloid Cell Leukemia 1 Inhibitors with High Affinity, Selectivity, and Oral Bioavailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.37 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297482 | AZD-5991 | 1.0 | 1 | 7.44 |
| CHEMBL4850731 | — | — | 1 | 6.44 |
| CHEMBL4872248 | — | — | 1 | 6.41 |
| CHEMBL4848900 | — | — | 1 | 6.32 |
| CHEMBL4848433 | — | — | 1 | 6.31 |
| CHEMBL4866213 | — | — | 1 | 6.16 |
| CHEMBL3417704 | — | — | 1 | 6.05 |
| CHEMBL4845828 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297482 | AZD-5991 | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4850731 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4872248 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4848900 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4848433 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4866213 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3417704 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4845828 | — | IC50 | = | 1390.0 | nM | 5.86 |