Assay Detail
ADMET
CHEMBL4837811
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Cytotoxicity against human WI-38 cells assessed as reduction in cell viability after 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | WI-38 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.86 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.47 |
| CHEMBL4876222 | — | — | 1 | 7.20 |
| CHEMBL4850245 | — | — | 1 | 6.97 |
| CHEMBL4860232 | — | — | 1 | 6.96 |
| CHEMBL2069933 | — | — | 1 | 6.93 |
| CHEMBL4850560 | — | — | 1 | 6.90 |
| CHEMBL4877251 | — | — | 1 | 6.83 |
| CHEMBL4866288 | — | — | 1 | 6.83 |
| CHEMBL4758512 | — | — | 1 | 6.78 |
| CHEMBL4878860 | — | — | 1 | 6.78 |
| CHEMBL4849370 | — | — | 1 | 6.76 |
| CHEMBL560774 | — | — | 1 | 6.73 |
| CHEMBL4849098 | — | — | 1 | 6.71 |
| CHEMBL1876217 | — | — | 1 | 6.63 |
| CHEMBL4859206 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 34.1 | nM | 7.47 |
| CHEMBL4876222 | — | IC50 | = | 62.9 | nM | 7.20 |
| CHEMBL4850245 | — | IC50 | = | 107.9 | nM | 6.97 |
| CHEMBL4860232 | — | IC50 | = | 110.8 | nM | 6.96 |
| CHEMBL2069933 | — | IC50 | = | 116.9 | nM | 6.93 |
| CHEMBL4850560 | — | IC50 | = | 126.1 | nM | 6.90 |
| CHEMBL4877251 | — | IC50 | = | 148.1 | nM | 6.83 |
| CHEMBL4866288 | — | IC50 | = | 148.5 | nM | 6.83 |
| CHEMBL4758512 | — | IC50 | = | 166.4 | nM | 6.78 |
| CHEMBL4878860 | — | IC50 | = | 166.4 | nM | 6.78 |
| CHEMBL4849370 | — | IC50 | = | 174.2 | nM | 6.76 |
| CHEMBL560774 | — | IC50 | = | 186.8 | nM | 6.73 |
| CHEMBL4849098 | — | IC50 | = | 196.2 | nM | 6.71 |
| CHEMBL1876217 | — | IC50 | = | 235.7 | nM | 6.63 |
| CHEMBL4859206 | — | IC50 | = | 352.3 | nM | 6.45 |