Assay Detail
Functional
CHEMBL4838014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei AQP1-3 KO trypomastigotes incubated for 48 hrs by resazurin dye based fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, biological, and photophysical studies of molecular rotor-based fluorescent inhibitors of the trypanosome alternative oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.13 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 7.47 |
| CHEMBL4878802 | — | — | 1 | 6.72 |
| CHEMBL4873996 | — | — | 1 | 6.47 |
| CHEMBL4857072 | — | — | 1 | 6.37 |
| CHEMBL4872515 | — | — | 1 | 6.36 |
| CHEMBL4879019 | — | — | 1 | 6.18 |
| CHEMBL4846979 | — | — | 1 | 5.98 |
| CHEMBL4857860 | — | — | 1 | 4.88 |
| CHEMBL4846671 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4878802 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4873996 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4857072 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4872515 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4879019 | — | EC50 | = | 663.0 | nM | 6.18 |
| CHEMBL4846979 | — | EC50 | = | 1048.0 | nM | 5.98 |
| CHEMBL4857860 | — | EC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL4846671 | — | EC50 | = | 16600.0 | nM | 4.78 |