Assay Detail
Binding
CHEMBL4838111
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FGFR1 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluations of a series of Pyrido[1,2-a]pyrimidinone derivatives as novel selective FGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.98 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297522 | PEMIGATINIB | 4.0 | 1 | 9.40 |
| CHEMBL1852688 | INFIGRATINIB | 4.0 | 1 | 9.05 |
| CHEMBL3545376 | ERDAFITINIB | 4.0 | 1 | 8.92 |
| CHEMBL3828009 | LY-2874455 | 1.0 | 1 | 8.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297522 | PEMIGATINIB | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1852688 | INFIGRATINIB | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3545376 | ERDAFITINIB | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3828009 | LY-2874455 | IC50 | = | 2.8 | nM | 8.55 |