Assay Detail
Binding
CHEMBL4838186
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Inhibition of AXL (unknown origin) by ELISA
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein kinase receptor UFO (CHEMBL4895) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 8.99 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4858468 | — | — | 1 | 10.00 |
| CHEMBL4855261 | — | — | 1 | 9.70 |
| CHEMBL4860162 | — | — | 1 | 9.70 |
| CHEMBL4877502 | — | — | 1 | 9.70 |
| CHEMBL4869472 | — | — | 1 | 9.40 |
| CHEMBL4875762 | — | — | 1 | 9.40 |
| CHEMBL4873716 | — | — | 1 | 9.40 |
| CHEMBL4873311 | — | — | 1 | 9.30 |
| CHEMBL4845677 | — | — | 1 | 9.30 |
| CHEMBL4851553 | — | — | 1 | 9.10 |
| CHEMBL4866647 | — | — | 1 | 9.10 |
| CHEMBL4871620 | — | — | 1 | 9.00 |
| CHEMBL4855494 | — | — | 1 | 8.96 |
| CHEMBL4865357 | — | — | 1 | 8.92 |
| CHEMBL4864971 | — | — | 1 | 8.74 |
| CHEMBL4849955 | — | — | 1 | 8.64 |
| CHEMBL4865839 | — | — | 1 | 8.57 |
| CHEMBL4877967 | — | — | 1 | 8.55 |
| CHEMBL4853092 | — | — | 1 | 8.52 |
| CHEMBL4847126 | — | — | 1 | 8.43 |
| CHEMBL4856684 | — | — | 1 | 8.40 |
| CHEMBL4858746 | — | — | 1 | 8.30 |
| CHEMBL4846616 | — | — | 1 | 8.29 |
| CHEMBL3809489 | BEMCENTINIB | 2.0 | 1 | 8.28 |
| CHEMBL4851027 | — | — | 1 | - |
| CHEMBL4871361 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4858468 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4855261 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4860162 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4877502 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4869472 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4875762 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4873716 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4873311 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4845677 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4851553 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4866647 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4871620 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4855494 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4865357 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4864971 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4849955 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4865839 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4877967 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4853092 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4847126 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4856684 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4858746 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4846616 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL3809489 | BEMCENTINIB | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4851027 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL4871361 | — | IC50 | < | 0.2 | nM | - |