Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4838702

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MERTK (unknown origin)
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase Mer (CHEMBL5331)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

UNC5293, a potent, orally available and highly MERTK-selective inhibitor.
Zheng H, Zhao J, Li B, Zhang W, Stashko MA, Minson KA, Huey MG, Zhou Y, Earp HS, Kireev D, Graham DK, DeRyckere D, Frye SV, Wang X.
Eur J Med Chem (2021) 220 : 113534 -113534
PubMed 34038857 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 35 8.44 9.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4877347 1 9.05
CHEMBL4857351 1 9.05
CHEMBL4866538 1 8.92
CHEMBL4862333 1 8.92
CHEMBL4867544 1 8.89
CHEMBL4856976 1 8.82
CHEMBL4847691 1 8.80
CHEMBL4851097 1 8.72
CHEMBL4877792 1 8.64
CHEMBL4857561 1 8.64
CHEMBL4878347 1 8.62
CHEMBL4850498 1 8.59
CHEMBL4847256 1 8.55
CHEMBL4875352 1 8.52
CHEMBL4849169 1 8.52
CHEMBL4877058 1 8.51
CHEMBL4854055 1 8.47
CHEMBL4878774 1 8.40
CHEMBL4862062 1 8.38
CHEMBL4868941 1 8.36
CHEMBL4875531 1 8.35
CHEMBL4853524 1 8.34
CHEMBL4878118 1 8.32
CHEMBL4854618 1 8.30
CHEMBL4851303 1 8.28
CHEMBL4873478 1 8.26
CHEMBL4846907 1 8.21
CHEMBL4861169 1 8.21
CHEMBL4845859 1 8.19
CHEMBL4848248 1 8.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4877347 IC50 = 0.9 nM 9.05
CHEMBL4857351 IC50 = 0.9 nM 9.05
CHEMBL4866538 IC50 = 1.2 nM 8.92
CHEMBL4862333 IC50 = 1.2 nM 8.92
CHEMBL4867544 IC50 = 1.3 nM 8.89
CHEMBL4856976 IC50 = 1.5 nM 8.82
CHEMBL4847691 IC50 = 1.6 nM 8.80
CHEMBL4851097 IC50 = 1.9 nM 8.72
CHEMBL4877792 IC50 = 2.3 nM 8.64
CHEMBL4857561 IC50 = 2.3 nM 8.64
CHEMBL4878347 IC50 = 2.4 nM 8.62
CHEMBL4850498 IC50 = 2.6 nM 8.59
CHEMBL4847256 IC50 = 2.8 nM 8.55
CHEMBL4875352 IC50 = 3.0 nM 8.52
CHEMBL4849169 IC50 = 3.0 nM 8.52
CHEMBL4877058 IC50 = 3.1 nM 8.51
CHEMBL4854055 IC50 = 3.4 nM 8.47
CHEMBL4878774 IC50 = 4.0 nM 8.40
CHEMBL4862062 IC50 = 4.2 nM 8.38
CHEMBL4868941 IC50 = 4.4 nM 8.36
CHEMBL4875531 IC50 = 4.5 nM 8.35
CHEMBL4853524 IC50 = 4.6 nM 8.34
CHEMBL4878118 IC50 = 4.8 nM 8.32
CHEMBL4854618 IC50 = 5.0 nM 8.30
CHEMBL4851303 IC50 = 5.2 nM 8.28
CHEMBL4873478 IC50 = 5.5 nM 8.26
CHEMBL4846907 IC50 = 6.2 nM 8.21
CHEMBL4861169 IC50 = 6.1 nM 8.21
CHEMBL4845859 IC50 = 6.5 nM 8.19
CHEMBL4848248 IC50 = 7.2 nM 8.14
CHEMBL4854016 IC50 = 7.9 nM 8.10
CHEMBL4866585 IC50 = 8.5 nM 8.07
CHEMBL4861342 IC50 = 9.5 nM 8.02
CHEMBL4855700 IC50 = 13.0 nM 7.89
CHEMBL4862025 IC50 = 30.0 nM 7.52