Compound Detail
CHEMBL4861169
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Cc1cc(C(=O)N2CCC(c3cn([C@H]4CC[C@H](O)CC4)c4nc(NCC5CCCCC5)ncc34)CC2)cc(C)n1
Basic Information
| ChEMBL ID | CHEMBL4861169 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MLEGYBAUGFHNOW-MCZWQBSQSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
544.7
MW (Da)
5.93
ALogP
7
HBA
2
HBD
96.2
PSA (Ų)
0.40
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase Mer CHEMBL5331 | IC50 | 8.21 | 8.21 | 6.1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 6.68 | 6.68 | 210.0 | 1 |
| Tyrosine-protein kinase receptor UFO CHEMBL4895 | IC50 | 6.23 | 6.23 | 590.0 | 1 |
| Tyrosine-protein kinase receptor TYRO3 CHEMBL5314 | IC50 | 5.93 | 5.93 | 1180.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase Mer | IC50 | = | 6.1 | nM | 8.21 | Inhibition of MERTK (unknown origin) | 34038857 |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 210.0 | nM | 6.68 | Inhibition of FLT3 (unknown origin) | 34038857 |
| Tyrosine-protein kinase receptor UFO | IC50 | = | 590.0 | nM | 6.23 | Inhibition of AXL (unknown origin) | 34038857 |
| Tyrosine-protein kinase receptor TYRO3 | IC50 | = | 1180.0 | nM | 5.93 | Inhibition of TYRO3 (unknown origin) | 34038857 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34038857 | 10.1016/j.ejmech.2021.113534 | Tyrosine-protein kinase Mer | 1 |
| 34038857 | 10.1016/j.ejmech.2021.113534 | Tyrosine-protein kinase receptor UFO | 1 |
| 34038857 | 10.1016/j.ejmech.2021.113534 | Tyrosine-protein kinase receptor TYRO3 | 1 |
| 34038857 | 10.1016/j.ejmech.2021.113534 | Receptor-type tyrosine-protein kinase FLT3 | 1 |
| 34038857 | 10.1016/j.ejmech.2021.113534 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine