Assay Detail
Binding
CHEMBL4838704
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Inhibition of TYRO3 (unknown origin)
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein kinase receptor TYRO3 (CHEMBL5314) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
UNC5293, a potent, orally available and highly MERTK-selective inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.00 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4847691 | — | — | 1 | 7.75 |
| CHEMBL4878774 | — | — | 1 | 7.48 |
| CHEMBL4850498 | — | — | 1 | 7.41 |
| CHEMBL4877347 | — | — | 1 | 7.38 |
| CHEMBL4867544 | — | — | 1 | 7.34 |
| CHEMBL4877058 | — | — | 1 | 7.32 |
| CHEMBL4878118 | — | — | 1 | 7.30 |
| CHEMBL4857561 | — | — | 1 | 7.29 |
| CHEMBL4862333 | — | — | 1 | 7.27 |
| CHEMBL4857351 | — | — | 1 | 7.23 |
| CHEMBL4862062 | — | — | 1 | 7.19 |
| CHEMBL4851097 | — | — | 1 | 7.19 |
| CHEMBL4851303 | — | — | 1 | 7.14 |
| CHEMBL4856976 | — | — | 1 | 7.14 |
| CHEMBL4847256 | — | — | 1 | 7.05 |
| CHEMBL4854618 | — | — | 1 | 7.05 |
| CHEMBL4848248 | — | — | 1 | 7.05 |
| CHEMBL4875352 | — | — | 1 | 7.02 |
| CHEMBL4877792 | — | — | 1 | 7.02 |
| CHEMBL4868941 | — | — | 1 | 7.01 |
| CHEMBL4875531 | — | — | 1 | 7.00 |
| CHEMBL4854055 | — | — | 1 | 7.00 |
| CHEMBL4846907 | — | — | 1 | 6.92 |
| CHEMBL4854016 | — | — | 1 | 6.92 |
| CHEMBL4845859 | — | — | 1 | 6.89 |
| CHEMBL4853524 | — | — | 1 | 6.89 |
| CHEMBL4878347 | — | — | 1 | 6.89 |
| CHEMBL4873478 | — | — | 1 | 6.85 |
| CHEMBL4849169 | — | — | 1 | 6.82 |
| CHEMBL4866538 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4847691 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4878774 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4850498 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4877347 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4867544 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4877058 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4878118 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4857561 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4862333 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4857351 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4862062 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4851097 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4851303 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4856976 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4848248 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4847256 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4854618 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4875352 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4877792 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4868941 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4875531 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4854055 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4846907 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4854016 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4878347 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4853524 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4845859 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4873478 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4849169 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4866538 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4861342 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4855700 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4866585 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4862025 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4861169 | — | IC50 | = | 1180.0 | nM | 5.93 |