Assay Detail
Binding
CHEMBL4838722
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST-tagged TYRO3 (453 to 890 residues) (unknown origin) cytoplasmic domain expressed in Sf21 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein kinase receptor TYRO3 (CHEMBL5314) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
UNC5293, a potent, orally available and highly MERTK-selective inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.17 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4283353 | — | — | 1 | 8.51 |
| CHEMBL4877347 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4283353 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4877347 | — | IC50 | = | 15.0 | nM | 7.82 |