Assay Detail
Binding
CHEMBL4838728
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST-tagged MELK (1 to 493 residues) (unknown origin) expressed in Escherichia coli
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Maternal embryonic leucine zipper kinase (CHEMBL4578) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
UNC5293, a potent, orally available and highly MERTK-selective inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.83 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4283353 | — | — | 1 | 8.64 |
| CHEMBL4877347 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4283353 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4877347 | — | IC50 | = | 95.7 | nM | 7.02 |