Assay Detail
Binding
CHEMBL4839367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kbeta (unknown origin) using PI(4,5)P2 as substrate incubated for 60 mins in presence of ATP by ADP-Glo kinase assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.24 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4869632 | — | — | 1 | 7.92 |
| CHEMBL4868400 | — | — | 1 | 7.92 |
| CHEMBL4870563 | — | — | 1 | 7.66 |
| CHEMBL4860779 | — | — | 1 | 7.44 |
| CHEMBL4852502 | — | — | 1 | 7.37 |
| CHEMBL4871998 | — | — | 1 | 7.20 |
| CHEMBL4875626 | — | — | 1 | 7.16 |
| CHEMBL4851439 | — | — | 1 | 6.93 |
| CHEMBL4849035 | — | — | 1 | 6.83 |
| CHEMBL4860129 | — | — | 1 | 6.75 |
| CHEMBL4873263 | — | — | 1 | 6.70 |
| CHEMBL4850640 | — | — | 1 | 6.29 |
| CHEMBL4863567 | — | — | 1 | 6.12 |
| CHEMBL4877926 | — | — | 1 | 5.79 |
| CHEMBL4857669 | — | — | 1 | 5.78 |
| CHEMBL4867528 | — | — | 1 | 5.67 |
| CHEMBL4851045 | — | — | 1 | 5.64 |
| CHEMBL4879247 | — | — | 1 | 5.46 |
| CHEMBL4860637 | — | — | 1 | 5.39 |
| CHEMBL4878956 | — | — | 1 | 5.30 |
| CHEMBL4868065 | — | — | 1 | 5.29 |
| CHEMBL4850455 | — | — | 1 | 5.29 |
| CHEMBL4873491 | — | — | 1 | 5.28 |
| CHEMBL4862738 | — | — | 1 | 5.19 |
| CHEMBL4855691 | — | — | 1 | 5.00 |
| CHEMBL4865476 | — | — | 1 | 4.95 |
| CHEMBL4847559 | — | — | 1 | - |
| CHEMBL4865490 | — | — | 1 | - |
| CHEMBL4864349 | — | — | 1 | - |
| CHEMBL4876439 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4869632 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4868400 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4870563 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4860779 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4852502 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4871998 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4875626 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4851439 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL4849035 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL4860129 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL4873263 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL4850640 | — | IC50 | = | 508.0 | nM | 6.29 |
| CHEMBL4863567 | — | IC50 | = | 762.0 | nM | 6.12 |
| CHEMBL4877926 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL4857669 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL4867528 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL4851045 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL4879247 | — | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL4860637 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL4878956 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4868065 | — | IC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL4850455 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL4873491 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4862738 | — | IC50 | = | 6450.0 | nM | 5.19 |
| CHEMBL4855691 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL4865476 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4847559 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4865490 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4864349 | — | IC50 | > | 18000.0 | nM | - |
| CHEMBL4876439 | — | IC50 | > | 20000.0 | nM | - |