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Assay Detail

CHEMBL4839424

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Binding
Inhibition of wild-type human full length GSK3A (M1 to S483 residues) expressed in bacterial expression system by Kinomescan method relative to control
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glycogen synthase kinase-3 alpha (CHEMBL2850)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.
Serafim RAM, Sorrell FJ, Berger BT, Collins RJ, Vasconcelos SNS, Massirer KB, Knapp S, Bennett J, Fedorov O, Patel H, Zuercher WJ, Elkins JM.
J Med Chem (2021) 64 : 13259 -13278
PubMed 34463505 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 6.24 6.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL156563 1 6.24

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL156563 Kd = 580.0 nM 6.24