Assay Detail
Binding
CHEMBL4839716
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Binding affinity to Sigma 2-receptor (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.76 | 9.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4853196 | — | — | 1 | 9.36 |
| CHEMBL4846092 | — | — | 1 | 8.07 |
| CHEMBL4865307 | — | — | 1 | 8.05 |
| CHEMBL4867297 | — | — | 1 | 7.96 |
| CHEMBL4848550 | — | — | 1 | 7.32 |
| CHEMBL4863873 | — | — | 1 | 7.30 |
| CHEMBL4876663 | — | — | 1 | 7.10 |
| CHEMBL4869437 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4853196 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL4846092 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL4865307 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL4867297 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4848550 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL4863873 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL4876663 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL4869437 | — | Ki | = | 120.0 | nM | 6.92 |