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Assay Detail

CHEMBL4840119

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of JNK2 (unknown origin) using biotinylated FL-ATF-2 as substrate measured after 22 mins by homogeneous time-resolved fluorescence analysis
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 9 (CHEMBL4179)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

<i>N</i>-Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors.
Feng Y, Park H, Ryu JC, Yoon SO.
ACS Med Chem Lett (2021) 12 : 1546 -1552
PubMed 34676036 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 6.74 7.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4874573 1 7.54
CHEMBL4857979 1 7.28
CHEMBL4845770 1 7.13
CHEMBL4872493 1 7.13
CHEMBL4877727 1 7.13
CHEMBL4874134 1 7.03
CHEMBL4859957 1 6.85
CHEMBL3355178 1 6.68
CHEMBL4851793 1 6.38
CHEMBL4864514 1 5.99
CHEMBL4847784 1 5.88
CHEMBL4753641 1 5.87
CHEMBL4876387 1 -
CHEMBL4875508 1 -
CHEMBL4869300 1 -
CHEMBL4853326 1 -
CHEMBL4879188 1 -
CHEMBL4875476 1 -
CHEMBL4865870 1 -
CHEMBL4861739 1 -
CHEMBL4847175 1 -
CHEMBL4867426 1 -
CHEMBL4874575 1 -
CHEMBL4853306 1 -
CHEMBL4876785 1 -
CHEMBL4854405 1 -
CHEMBL4863524 1 -
CHEMBL4872832 1 -
CHEMBL4862656 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4874573 IC50 = 29.0 nM 7.54
CHEMBL4857979 IC50 = 52.0 nM 7.28
CHEMBL4845770 IC50 = 74.0 nM 7.13
CHEMBL4872493 IC50 = 74.0 nM 7.13
CHEMBL4877727 IC50 = 74.0 nM 7.13
CHEMBL4874134 IC50 = 93.0 nM 7.03
CHEMBL4859957 IC50 = 140.0 nM 6.85
CHEMBL3355178 IC50 = 210.0 nM 6.68
CHEMBL4851793 IC50 = 414.0 nM 6.38
CHEMBL4864514 IC50 = 1020.0 nM 5.99
CHEMBL4847784 IC50 = 1330.0 nM 5.88
CHEMBL4753641 IC50 = 1360.0 nM 5.87
CHEMBL4876387 IC50 - -
CHEMBL4875508 IC50 - -
CHEMBL4869300 IC50 - -
CHEMBL4853326 IC50 - -
CHEMBL4879188 IC50 - -
CHEMBL4875476 IC50 - -
CHEMBL4865870 IC50 - -
CHEMBL4861739 IC50 - -
CHEMBL4847175 IC50 - -
CHEMBL4867426 IC50 - -
CHEMBL4874575 IC50 - -
CHEMBL4853306 IC50 - -
CHEMBL4876785 IC50 - -
CHEMBL4854405 IC50 - -
CHEMBL4863524 IC50 - -
CHEMBL4872832 IC50 - -
CHEMBL4862656 IC50 - -