Compound Detail
CHEMBL4859957
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4859957 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BQHWGFRFUSNBMX-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
2
PK Parameters
12
Publications
0
Known Names
Molecular Properties
415.9
MW (Da)
4.69
ALogP
6
HBA
2
HBD
71.8
PSA (Ų)
0.51
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 10 CHEMBL2637 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
| Mitogen-activated protein kinase 9 CHEMBL4179 | IC50 | 6.85 | 6.85 | 140.0 | 1 |
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 6.42 | 6.42 | 380.0 | 1 |
| Mitogen-activated protein kinase 8 CHEMBL2276 | IC50 | 6.06 | 6.06 | 872.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.4333 | hr | Homo sapiens |
| T1/2 | 0.2833 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 10 | IC50 | = | 12.0 | nM | 7.92 | Inhibition of JNK3alpha1 (unknown origin) using biotinylated FL-ATF-2 as substra... | 34676036 |
| Mitogen-activated protein kinase 9 | IC50 | = | 140.0 | nM | 6.85 | Inhibition of JNK2 (unknown origin) using biotinylated FL-ATF-2 as substrate mea... | 34676036 |
| Mitogen-activated protein kinase 14 | IC50 | = | 380.0 | nM | 6.42 | Inhibition of p38 alpha (unknown origin) using biotinylated FL-ATF-2 as substrat... | 34676036 |
| Mitogen-activated protein kinase 8 | IC50 | = | 872.0 | nM | 6.06 | Inhibition of JNK1 (unknown origin) using biotinylated FL-ATF-2 as substrate mea... | 34676036 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34676036 | 10.1021/acsmedchemlett.1c00334 | Unchecked | 3 |
| 34676036 | 10.1021/acsmedchemlett.1c00334 | ADMET | 2 |
| 34676036 | 10.1021/acsmedchemlett.1c00334 | Mitogen-activated protein kinase 10 | 1 |
| 34676036 | 10.1021/acsmedchemlett.1c00334 | Mitogen-activated protein kinase 8 | 1 |
| 34676036 | 10.1021/acsmedchemlett.1c00334 | Mitogen-activated protein kinase 9 | 1 |
| 34676036 | 10.1021/acsmedchemlett.1c00334 | Mitogen-activated protein kinase 14 | 1 |
| 34676036 | 10.1021/acsmedchemlett.1c00334 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 34676036 | 10.1021/acsmedchemlett.1c00334 | Cytochrome P450 1A2 | 1 |
| 34676036 | 10.1021/acsmedchemlett.1c00334 | Cytochrome P450 2C9 | 1 |
| 34676036 | 10.1021/acsmedchemlett.1c00334 | Cytochrome P450 2D6 | 1 |
| 34676036 | 10.1021/acsmedchemlett.1c00334 | Cytochrome P450 3A4 | 1 |
| 34676036 | 10.1021/acsmedchemlett.1c00334 | SH-SY5Y | 1 |
Data from ChEMBL 36 via Core Engine