Assay Detail
Binding
CHEMBL4840124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by automated Qpatch electrophysiological method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
<i>N</i>-Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.95 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4857979 | — | — | 1 | 5.05 |
| CHEMBL4845770 | — | — | 1 | 5.00 |
| CHEMBL4864514 | — | — | 1 | 4.80 |
| CHEMBL4753641 | — | — | 1 | - |
| CHEMBL4872493 | — | — | 1 | - |
| CHEMBL4847784 | — | — | 1 | - |
| CHEMBL4847175 | — | — | 1 | - |
| CHEMBL4874134 | — | — | 1 | - |
| CHEMBL4875508 | — | — | 1 | - |
| CHEMBL4851793 | — | — | 1 | - |
| CHEMBL4859957 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4857979 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4845770 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4864514 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL4753641 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4872493 | — | IC50 | - | — | - | |
| CHEMBL4847784 | — | IC50 | - | — | - | |
| CHEMBL4847175 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL4874134 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4875508 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL4851793 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4859957 | — | IC50 | > | 30000.0 | nM | - |