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Assay Detail

CHEMBL4840218

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania tropica (MHOM/SY/2012/ISS3130) promastigotes assessed as reduction in parasite viability measured after 72 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania tropica
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania tropica (CHEMBL612881)
Type ORGANISM
Organism Leishmania tropica

Publication

Development of Potent 3-Br-isoxazoline-Based Antimalarial and Antileishmanial Compounds.
Galbiati A, Zana A, Coser C, Tamborini L, Basilico N, Parapini S, Taramelli D, Conti P.
ACS Med Chem Lett (2021) 12 : 1726 -1732
PubMed 34795860 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.96 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL267345 AMPHOTERICIN B 4.0 1 6.92
CHEMBL4869051 1 6.51
CHEMBL4869503 1 5.28
CHEMBL4862588 1 5.16
CHEMBL4854616 1 5.12
CHEMBL4868264 1 4.96
CHEMBL4868878 1 4.83
CHEMBL4865319 1 4.60
CHEMBL4867348 1 4.59
CHEMBL4871534 1 4.49
CHEMBL4878292 1 4.47
CHEMBL4871929 1 4.47
CHEMBL4868589 1 4.41
CHEMBL4852746 1 4.37
CHEMBL4865981 1 4.29
CHEMBL3329248 1 -
CHEMBL4869813 1 -
CHEMBL76 CHLOROQUINE 4.0 1 -
CHEMBL4562798 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL267345 AMPHOTERICIN B IC50 = 120.0 nM 6.92
CHEMBL4869051 IC50 = 310.0 nM 6.51
CHEMBL4869503 IC50 = 5300.0 nM 5.28
CHEMBL4862588 IC50 = 6900.0 nM 5.16
CHEMBL4854616 IC50 = 7500.0 nM 5.12
CHEMBL4868264 IC50 = 10900.0 nM 4.96
CHEMBL4868878 IC50 = 14700.0 nM 4.83
CHEMBL4865319 IC50 = 24900.0 nM 4.60
CHEMBL4867348 IC50 = 25600.0 nM 4.59
CHEMBL4871534 IC50 = 32600.0 nM 4.49
CHEMBL4878292 IC50 = 33800.0 nM 4.47
CHEMBL4871929 IC50 = 33800.0 nM 4.47
CHEMBL4868589 IC50 = 39400.0 nM 4.41
CHEMBL4852746 IC50 = 43000.0 nM 4.37
CHEMBL4865981 IC50 = 50700.0 nM 4.29
CHEMBL3329248 IC50 - -
CHEMBL4869813 IC50 - -
CHEMBL76 CHLOROQUINE IC50 - -
CHEMBL4562798 IC50 - -