Assay Detail
Functional
CHEMBL4840272
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against antiretroviral-resistant HIV1 443 harboring reverse transcriptase K103N/D67N/K70R/Y115F/Q151M/M184V/K219Q mutant infected in human CEM-GXR cells assessed as inhibition of viral replication measured after 3 days by Flowcytometry assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM-GXR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
2-Trifluoromethylthiazole-5-carboxamides: Analogues of a Stilbene-Based Anti-HIV Agent that Impact HIV mRNA Processing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.28 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4845743 | — | — | 1 | 6.62 |
| CHEMBL4874932 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4845743 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4874932 | — | EC50 | = | 1160.0 | nM | 5.94 |